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崔鹏课题组

来源: 发布者: 时间:2020年02月10日

  崔鹏课题组

  Cui peng Lab

  课题组长

  崔鹏,研究员,博导,农科院青年英才,广东省特支计划青年人才,深圳市海外高层次人才。主要从事植物基因组学和生物信息学领域的研究工作,发表过的文章累计引用次数700余次。其中以第一作者及通讯作者身份发表过SCI论文近25篇,包括在领域内著名期刊Nature communications, the Plant cell、Genome biology、Molecular plant、Plos genetics等发表的文章。

 

  工作经历

  2016.5-至今        中国农科院农业基因组研究所      研究员                         

  2012.4-2016.4    沙特阿卜杜拉国王科技大学         研究科学家                     

  2011.4-2012.3    美国威斯康辛医学院癌症中心      博士后                         

  2010.2-2011.3    沙特阿卜杜拉国王科技大学         研究科学家                     

  2009.8-2010.1    中科院北京基因组研究所             研究助理    

                   

  教育经历

  中国科学院北京基因组研究所          博士学位           2004.9-2009.7

  沈阳化工大学                                  学士学位           2000.9-2004.7

 

  团队研究方向

  研究方向主要集中在基因组学领域分析和实验新方法开发,并应用到农业作物(重点集中在工业油料作物)基因组学研究。一方面,课题组目前研发基因组分析的新技术,主攻基因组结构和功能注释的新算法,改进基因组注释的准确性,使其流程自动化。另一方面,对一些油料植物(包括油桐树、蓖麻、向日葵)的基因组进行从头测序、拼接和重测序来开展研究工作,不断挖掘油料植物基因学新知识,同时展开对油料作物群体遗传学研究。挖掘控制重要农艺性状基因,为油料作物分子育种提供理论基础。

 

  研究进展

  研究团队主要致力于利用基因组学推动蓖麻等主要工业油料作物的分子设计育种。最近取得研究进展如下:1)针对中国蓖麻遗传背景欠缺的问题,完成蓖麻基因组精细图谱的构建,并通过对405份中国蓖麻品种的基因组重测序,完整的揭示了全基因组水平遗传变异的基本形式,推动了蓖麻分子设计育种技术体系的构建。2)全面揭示了中国蓖麻种群的地域分布以及表型和遗传分化情况,并揭示了蓖麻重要农业性状在人工驯化和品种地域分化过程中的演变以及内在的分子机制。3)通过全基因组关联分析(GWAS),鉴定控制蓖麻重要农业性状(包括种子大小、种子长度、百粒重、株高、穗高、穗长、果皮厚度和雌雄花数量比例)的基因以及优势基因型,为分子育种提供靶标。

 

 

  PI

  Peng Cui, Principle Investigator, Doctoral Advisor[z2] , “Outstanding Young Talent” of Chinese Academy of Agricultural Science (CAAS), top talent of Guangdong Tezhi Plan, overseas High-Caliber Personnel. He is mainly engaged in the field of plant genomics and bioinformatics. He has already published 25 papers at the international journals including Nature communicaitons, Plant cell, Genome biology, Molecular Plant, Plos genetics, etc., as the first or corresponding author. The publication has been cited more than 700 times.

 

  Working Experience

  2016.05–Present    Agricultural Genomics Institute at Shenzhen-CAAS         Professor 

  2012.04-2016.04   King Abdullah University of Science and Technology, KSA  Research Scientist

  2011.04-2012.03  Medical college of Wisconsin, USA   Postdoctoral Fellow

  2010.02-2011.03   King Abdullah University of Science and Technology, KSA  Research Scientist

  2009.08-2010.01  Beijing Institute of Genomics, CAS  Researcher Fellow

 

  Education

  2004.9-2009.7    Beijing Institute of Genomics, CAS                         Ph.D                        

  2000.9-2004.7    Shenyang University of Chemical Technology        Bachelor 

 

  Research Interest

  The research focuses on the development of new analysis and experimental methods in genomics, with an application on oil crop genomics research. On one hand, the research team is currently developing new techniques for genome analysis, focusing on new algorithms for genomic annotations, improving the accuracy of genome annotations, reducing human involvement, and automating processes. On the other hand, the team is studying on the genomes of some oil plants (including Tung tree, castor, sunflower), to explore new knowledge of oil plant genome and identify the key genes controlling important agronomic trait. The work provides a theoretical basis for molecular breeding of oil crops.

  

  Major Achievements

  The research team is committed to using genomics to promote molecular design and breeding of castor and other major industrial oil crops。Recent research progress is as follows: 1) in view of the lack of genetic background of castor in China, through the genome sequencing of 405 Chinese castor varieties, we completely revealed genetic variations at the whole genome level, and promoted the construction of castor molecular design and breeding technology system; 2)The work comprehensively revealed the regional distribution, phenotype and genotype differentiation of castor population in China, and revealed the molecular evolutionary mechanism of important agricultural traits of castor in the process of domestication and regional differentiation of varieties;3) Through genome-wide association analysis (GWAS), the genes and dominant genotypes controlling the important agricultural traits of castor (including seed size, seed length, hundred grain weight, plant height, ear height, ear length, peel thickness and the proportion of male and female flowers) were identified, which provides the potential targets for molecular breeding.

 

  Selected Publication 

  1.Wei Fan, Jianjun Lu, Pan Cheng, Meilian Tan, Qiang Lin, Wanfei Liu, Donghai Li, Lijun Wang, Lianlian Hu, Wang Lei, Chen Chen, Ai-Min Wu, Xinxin Yu, Ruan Jue, Jun Yu, Songnian Hu, Xingchu Yan*, Shiyou Lü*, Peng Cui*. Sequencing of Chinese Castor Lines Reveals Genetic Signatures of Selection and Yield-associated Loci. Nature Communications 2019 Jul 31;10(1):3418.

  2. Cui P, Lin Q, Fang D, Zhang L, Li R, Cheng J, et al. Tung Tree (Vernicia fordii, Hemsl.) Genome and Transcriptome Sequencing Reveals Co-Ordinate Up-Regulation of Fatty Acid beta-Oxidation and Triacylglycerol Biosynthesis Pathways During Eleostearic Acid Accumulation in Seeds. Plant Cell Physiol. 2018;59(10):1990-2003.

  3.Cui P*, Cheng Z*, et al. De novo genome assembly of Oryza granulata reveals rapid genome expansion and adaptive evolution. Communications Biology 2018;1.

  4. Cui P, Chen T, Ding F, Ali S, Xiong L. The protein phosphatase FRY2 interacts with eIF4AIII and UPF3 and is essential for nonsense-mediated mRNA decay in Arabidopsis, The Plant Cell 2016, 28(3):770-85.

  5. Cui P, Xiong L. Environmental Stress and Pre-mRNA Splicing. Molecular Plant 2015, p1302–1303.

  6. Cui P, Zhang S, Ding F, Ali S, Xiong L: Dynamic regulation of genome-wide pre-mRNA splicing and stress tolerance by the Sm-like protein LSm5 in Arabidopsis. Genome Biology 2014, 15:R1.

  7. Ding F, Cui P*, Wang Z, Zhang S, Ali S, Xiong L: Genome-wide analysis of alternative splicing of pre-mRNA under salt stress in Arabidopsis. BMC genomics 2014, 15:431.

  

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